02095nas a2200217   4500008004100000022001400041245011400055210006900169260000900238300001200247490000900259520141200268100002201680700002501702700001801727700001901745700002301764700002301787700001901810856004801829       2016                        eng d  a1942-099400aPhenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats.0 aPhenolic Rich Extract from Clinacanthus nutans Attenuates Hyperl  c2016  a41379080 v20163 a<p>Clinacanthus nutans is used as traditional medicine in Asia but there are limited scientific studies to support its use. In this study, the stem and leaf of C. nutans were extracted using solvents of differing polarities, and their antioxidant capacities were determined using multiple antioxidant assays. The water and aqueous methanolic leaf extracts were further fractionated and their antioxidant capacities and phenolic compositions were tested. Furthermore, the efficacies of the water and aqueous methanolic leaf extracts were tested against hyperlipidemia-induced oxidative stress in rats. Serum and hepatic antioxidant and oxidative stress markers were tested after feeding the rats with high fat diet together with the extracts or simvastatin for 7 weeks. The results indicated that both leaf extracts attenuated oxidative stress through increasing serum antioxidant enzymes activity and upregulating the expression of hepatic antioxidant genes. Multiple phenolic compounds were detected in the extracts and fractions of C. nutans, although protocatechuic acid was one of the most abundant and may have contributed significantly towards the bioactivities of the extracts. However, synergistic effects of different phenolics may have contributed to the overall bioactivities. C. nutans can be a good source of functional ingredients for the management of oxidative stress-related diseases.</p>
1 aSarega, Nadarajan1 aImam, Mustapha, Umar1 aOoi, Der-Jiun1 aChan, Kim, Wei1 aEsa, Norhaizan, Md1 aZawawi, Norhasnida1 aIsmail, Maznah  uhttps://acanthaceaeth.myspecies.info/node/200329nas a2200097   4500008004100000245004700041210004700088100002600135700002200161856004800183       2003                        eng d00aEthnobotany in upper northeastern Thailand0 aEthnobotany in upper northeastern Thailand1 aChamratpan, Seewapong1 aHomchuen, Sam-ang  uhttps://acanthaceaeth.myspecies.info/node/1